Publikationen
2024
Schreiber T, Koopmann I, Brandstetter J, Talbot SR, Goldstein L, Hoffmann L, Schildt A, Joksch M, Krause B, Jaster R, Palme R, Zechner D, Vollmar B, Kumstel S. Evidence-Based Severity Assessment of Animal Models for Pancreatic Cancer. Biomedicines 2024; 12(7):1494. doi: 10.3390/biomedicines12071494
Schulz B, Leitner E, Schreiber T, Lindner T, Schwarz R, Aboutara N, Ma Y, Escobar HM, Palme R, Hinz B, Vollmar B, Zechner D. Sex Matters-Insights from Testing Drug Efficacy in an Animal Model of Pancreatic Cancer. Cancers (Basel). 2024 May 16;16(10):1901. doi: 10.3390/cancers16101901.
Schweins M, Gäbel R, Raitza M, Vasudevan P, Lemcke H, Joksch M, Schildt A, Kurth J, Lindner T, Meinel FG, Öner A, Ince H, Vollmar B, Krause BJ, David R, Lang CI. Multi-modal assessment of a cardiac stem cell therapy reveals distinct modulation of regional scar properties. J Trans Med. 2024 Feb;22(1):187. doi: 10.1186/s12967-024-04986-2.
Polei S, Lindner T, Abshagen K, Liebig M, Krause BJ, Vollmar B, Weber MA. 7 Tesla MRI Liver Fat Quantification in Mice: Data Quality Assessment. Curr Med Imaging. 2024 Feb; 20. doi: 10.2174/0115734056263741231117112245.
2023
Koller L, Joksch M, Schwarzenböck S, Kurth J, Heuschkel M, Holzleitner N, Beck R, von Amsberg G, Wester HJ, Krause BJ, Günther T. Preclinical Comparison of the 64Cu- and 68Ga-Labeled GRPR-Targeted Compounds RM2 and AMTG, as Well as First-in-Humans [68Ga]Ga-AMTG PET/CT. J Nucl Med. 2023 Oct;64(10):1654-1659. doi: 10.2967/jnumed.123.265771.
König J, Rahn A, Schätzel J, Frank M, Stahnke T, Witt M, Stachs A, Stachs O, Langner I, Lindner T, Beller E, Fischer DC, Streckenbach F. Effects of prenatal Doppler ultrasound on the retina of the chick embryo in ovo. Anat Histol Embryol. 2023 Sep 5. doi: 10.1111/ahe.12960.
Vasudevan P, Wolfien M, Lemcke H, Lang CI, Skorska A, Gaebel R, Galow AM, Koczan D, Lindner T, Bergmann W, Mueller-Hilke B, Vollmar B, Krause BJ, Wolkenhauer O, Steinhoff G, David R. CCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation. Genome Med. 2023 Aug 10;15(1):61. doi: 10.1186/s13073-023-01213-3.
Müller L, Power Guerra N, Schildt A, Lindner T, Stenzel J, Behrangi N, Bergner C, Alberts T, Bühler D, Kurth J, Krause BJ, Janowitz D, Teipel S, Vollmar B, Kuhla A. [18F]GE-180-PET and Post Mortem Marker Characteristics of Long-Term High-Fat-Diet-Induced Chronic Neuroinflammation in Mice. Biomolecules. 2023 Apr 28;13(5):769. doi: 10.3390/biom13050769.
Streckenbach F, Jäschke M, Jahns N, Langner I, König J, Wree A, Stahnke T, Stachs O, Frank M, Langner S, Lindner T. MR microscopy of the developing upper extremity of the chicken in ovo using 7 Tesla MRI. Anat Histol Embryol. 2023 May;52(3):356-362. doi: 10.1111/ahe.12894.
2022
Massing T, Will K, Müller M, Aleith J, Lindner T, Warkentin M, Müller-Hilke B and Mittlmeier T. Prolonged treadmill training is not able to prevent ovariectomy-induced bone loss. Front. Physiol. 2022, 13:1078857. doi: 10.3389/fphys.2022.1078857
Streckenbach F, Leifert G, Beyer T, Mesanovic A, Wäscher H, Cantré D, Langner S, Weber MA, Lindner T. Application of a Deep Learning Approach to Analyze Large-Scale MRI Data of the Spine. Healthcare (Basel). 2022 Oct 26;10(11):2132. doi: 10.3390/healthcare10112132
Behrangi N, Heinig L, Frintrop L, Santrau E, Kurth J, Krause B, Atanasova D, Clarner T, Fragoulis A, Joksch M, Rudolf H, Meuth SG, Joost S, Kipp M. Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204509119. doi: 10.1073/pnas.2204509119.
Kumstel S, Schreiber T, Goldstein L, Stenzel J, Lindner T, Joksch M, Zhang X, Wendt EHU, Schönrogge M, Krause B, Vollmar B, Zechner D. Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism. PLoS One. 2022 Apr 22;17(4):e0266601. doi: 10.1371/journal.pone.0266601
Salewski I, Henne J, Engster L, Krone P, Schneider B, Redwanz C, Lemcke H, Henze L, Junghanss C, Maletzki C. CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors. Oncoimmunology. 2022 Jul 11;11(1):2094583. doi: 10.1080/2162402X.2022.2094583.
Andree A, Li N, Butenko K, Kober M, Chen J Z, Higuchi T, Fauser M, Storch A, Ip C W, Kühn A A, Horn A, van Rienen U. Deep brain stimulation electrode modeling in rats. Exp. Neurol. 2022 Apr:350:113978. doi: 10.1016/j.expneurol.2022.113978.
Alberts T, Antipova V, Holzmann C, Hawlitschka A, Schmitt O, Kurth J, Stenzel J, Lindner T, Krause BJ, Wree A, and Witt M. 2022. Olfactory Bulb D2/D3 Receptor Availability after Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease. Toxins 14, no. 2: 94. doi.org/10.3390/toxins14020094
2021
Stahnke T, Lindner T, Guthoff R, Stachs O, Wree A, Langner S, Niendorf T, Grabow N, Glass Ä, Beller E, Polei S. Ultrahigh field MRI determination of water diffusion rates in ex vivo human lenses of different age. Quant Imaging Med Surg. 2021 Jul;11(7):3029-3041. doi: 10.21037/qims-20-1124.
Jastram A, Lindner T, Luebbert C, Sadowski G, Kragl U. Swelling and Diffusion in Polymerized Ionic Liquids-Based Hydrogels. Polymers. 13(11):1834, 2021. doi: 10.3390/polym13111834.
Lang CI, Vasudevan P, Döring P, Gäbel R, Lemcke H, Lindner T, Steinhoff G, Krause BJ, Vollmar B, Meinel FG, Yücel S, Öner A, Ince H, David R. Expedient assessment of post-infarct remodeling by native cardiac magnetic resonance imaging in mice. Sci Rep. 11(1):11625, 2021. doi: 10.1038/s41598-021-91096-4.
Kordt M, Trautmann I, Schlie C, Lindner T, Stenzel J, Schildt A, Boeckmann L, Bekeschus S, Kurth J, Krause BJ, Vollmar B, Grambow E. Multimodal Imaging Techniques to Evaluate the Anticancer Effect of Cold Atmospheric Pressure Plasma. Cancers (Basel). 13(10):2483, 2021. doi: 10.3390/cancers13102483.
Salewski I, Kuntoff S, Kuemmel A, Feldtmann R, Felix SB, Henze L, Junghanss C, Maletzki C. Combined vaccine-immune-checkpoint inhibition constitutes a promising strategy for treatment of dMMR tumors. Cancer Immunol Immunother. 2021 Dec;70(12):3405-3419. doi: 10.1007/s00262-021-02933-4.
Salewski I, Henne J, Engster L, Schneider B, Lemcke H, Skorska A, Berlin P, Henze L, Junghanss C, Maletzki C. Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors. Int J Mol Sci 22 (11), 2021. doi: 10.3390/ijms22115990.
Müller L, Power Guerra N, Stenzel J, Rühlmann C, Lindner T, Krause BJ, Vollmar B, Teipel S, Kuhla A. Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice. Nutrients. 13(3):985, 2021. doi: 10.3390/nu13030985.
Rühlmann C, Dannehl D, Brodtrück M, Adams AC, Stenzel J, Lindner T, Krause BJ, Vollmar B, Kuhla A. Neuroprotective Effects of the FGF21 Analogue LY2405319. J Alzheimers Dis. 80(1):357-369, 2021. doi: 10.3233/JAD-200837.
Engel N, Fechner C, Voges A, Ott R, Stenzel J, Siewert S, Bergner C, Khaimov V, Liese J, Schmitz K-P, Krause B J, Frerich B. An optimized 3D-printed perfusion bioreactor for homogeneous cell seeding in bone substitute scaffolds for future chairside applications. Sci Rep. 11 (1):22228, 2021. doi: 10.1038/s41598-021-01516-8.
2020
Lindner T, Stenzel J, Koslowski N, Hohn A, Glass Ä, Schwarzenböck SM, Krause BJ, Vollmar B, Reisinger EC, Sombetzki M. Anatomical MRI and [18F]FDG PET/CT imaging of Schistosoma mansoni in a NMRI mouse model. Sci Rep 10(1):17343, 2020. doi: 10.1038/s41598-020-74226-2.
Kuhla A, Meuth L, Stenzel J, Lindner T, Lappe C, Kurth J, Krause BJ, Teipel S, Glass Ä, Kundt G, Vollmar B. Longitudinal [18F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice. EJNMMI Res 10(1):119, 2020. doi: 10.1186/s13550-020-00711-4.
Latza J, Otte M, Lindner T, Fischer DC, Bruhn S, Hollinski R, Warkentin M, Mittlmeier T, Müller-Hilke B. Interval Training Is Not Superior to Endurance Training With Respect to Bone Accrual of Ovariectomized Mice. Front Physiol 11:1096, 2020. doi: 10.3389/fphys.2020.01096.
Vasudevan P, Wolfien M, Lemcke H, Lang CI, Skorska A, Gaebel R, Koczan D, Lindner T, Engelmann R, Vollmar B, Krause BJ, Wolkenhauer O, Lang H, Steinhoff G, David R. Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells 9(8):E1825, 2020. doi: 10.3390/cells9081825.
Lang CI, Döring P, Gäbel R, Vasudevan P, Lemcke H, Müller P, Stenzel J, Lindner T, Joksch M, Kurth J, Bergner C, Wester HJ, Ince H, Steinhoff G, Vollmar B, David R, Krause BJ. [68Ga]-NODAGA-RGD Positron Emission Tomography (PET) for Assessment of Post Myocardial Infarction Angiogenesis as a Predictor for Left Ventricular Remodeling in Mice after Cardiac Stem Cell Therapy. Cells 9(6):1358, 2020. doi: 10.3390/cells9061358.
Vasudevan P, Gäbel R, Stenzel J, Förster J, Kurth J, Vollmar B, Krause BJ, Ince H, David R, Lang CI. 18F-FDG PET-Based Imaging of Myocardial Inflammation Following Acute Myocardial Infarction in a Mouse Model. Int J Mol Sci 21(9):3340, 2020. doi: 10.3390/ijms21093340.
2019
Stenzel J, Rühlmann C, Lindner T, Polei S, Teipel S, Kurth J, Rominger A, Krause BJ, Vollmar B, Kuhla A. [18F]-florbetaben PET/CT Imaging in the Alzheimer's Disease Mouse Model APPswe/PS1dE9. A. Curr Alzheimer Res 16(1):49-55, 2019. doi: 10.2174/1567205015666181022095904.
Mann T, Kurth J, Möller A, Förster J, Vollmar B, Krause BJ, Wree A, Stenzel J, Lindner T. Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function. J Vis Exp doi: 10.3791/59701, 2019. doi: 10.3791/59701.
Vasudevan P, Gaebel R, Doering P, Mueller P, Lemcke H, Stenzel J, Lindner T, Kurth J, Steinhoff G, Vollmar B, Krause BJ, Ince H, David R, Lang CI. 18F-FDG PET-Based Imaging of Myocardial Inflammation Predicts a Functional Outcome Following Transplantation of mESC-Derived Cardiac Induced Cells in a Mouse Model of Myocardial Infarction. Cells 8(12):1613, 2019. doi: 10.3390/cells8121613.
Hiemer B, Genz B, Ostwald J, Jonitz-Heincke A, Wree A, Lindner T, Tischer T, Dommerich S, Bader R. Repair of cartilage defects with devitalized osteochondral tissue: A pilot animal study. J Biomed Mater Res B Appl Biomater 107(7):2354-2364, 2019. doi: 10.1002/jbm.b.34329.
Streckenbach F, Klose R, Langner S, Langner I, Frank M, Wree A, Neumann AM, Glass Ä, Stahnke T, Guthoff RF, Stachs O, Lindner T. Ultrahigh-Field Quantitative MR Microscopy of the Chicken Eye In Vivo Throughout the In Ovo Period. Mol Imaging Biol 21(1):78-85, 2019. doi: 10.1007/s11307-018-1208-9.
Maletzki C, Wiegele L, Nassar I, Stenzel J, Junghanss C. Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer. J Immunother Cancer 7(1):8, 2019. doi: 10.1186/s40425-018-0476-x.
2018
Zhang X, Schönrogge M, Eichberg J, Wendt EHU, Kumstel S, Stenzel J, Lindner T, Jaster R, Krause BJ, Vollmar B, Zechner D. Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells. Front Oncol 8:590, 2018. doi: 10.3389/fonc.2018.00590.
Gabler C, Saß JO, Gierschner S, Lindner T, Bader R, Tischer T. In Vivo Evaluation of Different Collagen Scaffolds in an Achilles Tendon Defect Model. Biomed Res Int 2018:6432742, 2018. doi: 10.1155/2018/6432742.
Roolf C, Richter A, Konkolefski C, Knuebel G, Sekora A, Krohn S, Stenzel J, Krause BJ, Vollmar B, Murua Escobar H, Junghanss C. Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements. J Hematol Oncol 11(1):62, 2018. doi: 10.1186/s13045-018-0607-3.
Mann T, Kurth J, Hawlitschka A, Stenzel J, Lindner T, Polei S, Hohn A, Krause BJ, Wree A. [18F]fallypride-PET/CT Analysis of the Dopamine D₂/D₃ Receptor in the Hemiparkinsonian Rat Brain Following Intrastriatal Botulinum Neurotoxin A Injection. Molecules 23(3):587, 2018. doi: 10.3390/molecules23030587.
Hollinski R, Osterberg A, Polei S, Lindner T, Cantré D, Mittlmeier T, Vollmar B, Bruhn S, Müller-Hilke B. Young and healthy C57BL/6 J mice performing sprint interval training reveal gender- and site-specific changes to the cortical bone. Sci Rep 8(1):1529, 2018. doi: 10.1038/s41598-018-19547-z.
2017
Maletzki C, Gladbach Y, Hamed M, Fuellen G, Semmler ML, Stenzel J, Linnebacher M. Cellular vaccination of MLH1 mice-/-–an immunotherapeutic proof of concept study. OncoImmunology 7(3):e1408748, 2017. doi: 10.1080/2162402X.2017.1408748.
Kopp F, Eickner T, Polei S, Falke K, Witt M, Grabow N, Stachs O, Guthoff RF, Lindner T. Ultrahigh field MR imaging of a subconjunctival anti-glaucoma drug delivery system in a rabbit model. Sci Rep 7(1):15780, 2017. doi: 10.1038/s41598-017-15954-w.
Klose R, Streckenbach F, Hadlich S, Stahnke T, Guthoff R, Wree A, Frank M, Langner S, Stachs O, Lindner T. Ultra-high-field MRI in the Chicken Embryo in Ovo - a Model for Experimental Ophthalmology. Klin Monbl Augenheilkd 234(12):1458-1462, 2017. doi: 10.1055/s-0043-120675.
Schwarzenböck SM, Stenzel J, Otto T, Helldorff HV, Bergner C, Kurth J, Polei S, Lindner T, Rauer R, Hohn A, Hakenberg OW, Wester HJ, Vollmar B, Krause BJ. [68Ga]pentixafor for CXCR4 imaging in a PC-3 prostate cancer xenograft model - comparison with [18F]FDG PET/CT, MRI and ex vivo receptor expression. Oncotarget 8(56):95606-95619, 2017. doi: 10.18632/oncotarget.21024.
Rohde S, Lindner T, Polei S, Stenzel J, Borufka L, Achilles S, Hartmann E, Lange F, Maletzki C, Linnebacher M, Glass Ä, Schwarzenböck SM, Kurth J, Hohn A, Vollmar B, Krause BJ, Jaster R. Application of in vivo imaging techniques to monitor therapeutic efficiency of PLX4720 in an experimental model of microsatellite instable colorectal cancer. Oncotarget 8(41):69756-69767, 2017. doi: 10.18632/oncotarget.19263.
Kuhla A, Rühlmann C, Lindner T, Polei S, Hadlich S, Krause BJ, Vollmar B, Teipel SJ. APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study. Neuroimage Clin 15:581-586, 2017. doi: 10.1016/j.nicl.2017.06.009.
Schmidt A, Woedtke TV, Stenzel J, Lindner T, Polei S, Vollmar B, Bekeschus S. One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet. Int J Mol Sci 18(4), 2017. doi: 10.3390/ijms18040868.
Polley C, Mau R, Lieberwirth C, Stenzel J, Vollmar B, Seitz H. Bioprinting of three dimensional tumor models: a preliminary study using a low cost 3D printer. Current Directions in Biomedical Engineering 3(2): 135–138, 2017. doi: 10.1515/cdbme-2017-0084.
2016
Langner I, Stahnke T, Stachs O, Lindner T, Kühn JP, Kim S, Wree A, Langner S. MR microscopy of the human fetal upper extremity - a proof-of-principle study. BMC Dev Biol 16(1):21, 2016. doi: 10.1186/s12861-016-0123-z.
2015
Langner I, Stahnke T, Stachs O, Lindner T, Kühn JP, Kim S, Wree A, Langner S. MR microscopy of the human fetal upper extremity - a proof-of-principle study. BMC Dev Biol 16(1):21, 2015. doi: 10.1186/s12861-016-0123-z.
Lehner S, Lang C, Kaissis G, Todica A, Zacherl MJ, Boening G, Spitzweg C, Herbach N, Franz WM, Krause BJ, Steinhoff G, Bartenstein P, Hacker M, David R. (124)I-PET Assessment of Human Sodium Iodide Symporter Reporter Gene Activity for Highly Sensitive In Vivo Monitoring of Teratoma Formation in Mice. Mol Imaging Biol (6):874-83, 2015. doi: 10.1007/s11307-015-0857-1.
Zechner D, Bürtin F, Amme J, Lindner T, Radecke T, Hadlich S, Kühn JP, Vollmar B. Characterization of novel carcinoma cell lines for the analysis of therapeutical strategies fighting pancreatic cancer. Cell Biosci 5:51, 2015. doi: 10.1186/s13578-015-0038-6.